The new “day” guidance does not itself reduce the number of days USCIS gives you to answer an RFE.If your RFE establishes a response period measured in days and you are responding by paper, the next-business-day rule can still apply when the final day falls on a weekend or federal holiday.

Separately, an RFE response period generally cannot exceed 12 weeks, but USCIS may provide a shorter response period. The deadline printed on the notice controls.